ackground : although blood lipids and lipoproteins are closely related to coronary atherosclerosis, their association with cerebravascular atherosclerosis is less clearly understood. Methods : in order to study the
relationship of
plasma lipids and apolipoprotens to cerebral infarction, plasma lipid and apolipoprtein levels were measured in 23 male survivors of cerebral infarction and in 39 agematched male healthy controls. Plasma concentrations of lipid
were
measured by conventional methods and apolipoprteins by Rocket immunoelectrophoresis.
Results : the mean values of total cholesterol : 178±28.8 mg/dl, low density
lipoprotein-cholesterol(LDL-C) : 117±31.6 mg/dl and aplipoprotein B: 100±21.7 mg/dl were
significantly higher in the patients group than in the controls repectively, 160±30.3 mg/dl, 94±
28.9 mg/dl and 84±14.5 mg/dl (p<0.05, p<0.01 and p<0.01).
The concentration of apolipoprotein A-Ⅱ : 59±11.7mg/dll was significantly lower in the
group of patients than 70±7.9mg/dll in the controlds (p<0.001). The concentrations of
triglyceride, high density lipoproteincholesterol (HDL-C) and apolipoprotein A-Ⅰ showed no
significant differences between the two groups. The apoliporotein A-Ⅰ/apoliporotein A-Ⅱ ratio
was significantly higher in the group of patients than in controls, but total
cholesterol/LDL-cholesterol ratio and apolipoprotein A-Ⅱ/apolipoprotein B ratio were
signfiicantly lower in the group of patients.
Conclusions : this study showed the differences in lipid components and apolipoprotein
concentration between patients with cerebral infarction and agematched controls. Thus the
measurement of apolipoprotein concentration might be a useful parameter in assessing the risk
factors of cerebravascular diseases, expecially cerebral infarction.
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